The article reviews the best-performing Nasdaq-100 stocks of 2026 through October 14. Moderna leads with a 667% gain since the end of 2025, driven mainly by encouraging phase 3 results for intismeran autogene in certain melanoma types in mid-August, plus an FDA approval of a flu vaccine and its addition to the Nasdaq-100. Sandisk is up more than 490% year-to-date on AI-driven memory demand that pushed DRAM prices roughly 50% higher recently and about 400% above early 2024 levels, yet its shares have stalled and pulled back from a July peak. Micron, up 220% since the end of 2025 after gaining over 250% last year, has slowed similarly, with the analyst consensus 12-month target of $1,612 still more than 90% above its current price. The author warns that much of this growth may already be priced in, and that repeating Moderna's gain would be a tough act to follow.
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