The article highlights four high-risk stocks with big return potential: Joby Aviation (JOBY), Viking Therapeutics (VKTX), Navitas Semiconductor (NVTS), and Agios Pharmaceuticals (AGIO), while stressing that investors must weigh the risks. The FDA is conducting a priority review of Agios's sNDA for mitapivat to treat sickle cell disease, with a response due by Nov. 1, and Wall Street consensus expects this indication to contribute about a third of company revenue by 2030. Navitas is shifting toward higher-power chips for AI data centers, with management projecting a $3.5 billion serviceable addressable market in 2030 versus revenue of less than $50 million in 2026, though profitability is still a few years away. Joby is pursuing a transportation-as-a-service model and has flown an autonomous converted Cessna despite lacking FAA certification, while Viking's VK2735 is in phase 3 subcutaneous trials and an oral version is set to begin phase 3.
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